IP7e


CAS No. : 500164-74-9

500164-74-9
Price and Availability of CAS No. : 500164-74-9
Size Price Stock
5mg $140 In-stock
10mg $210 In-stock
25mg $490 In-stock
50mg $784 In-stock
100mg $1254 In-stock
200 mg Get quote
500 mg Get quote
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Cat. No. : HY-110274
M.Wt: 390.43
Formula: C23H22N2O4
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 500164-74-9 :

IP7e is a potent, brain-penetrant and orally active Nurr1 activator with an EC50 value of 3.9 nM[1]. IC50 & Target:EC50: 3.9 nM (Nurr1)[1] In Vivo:IP7e (Isoxazolo-pyridinone 7e; 10 mg/kg; oral gavage; twice a day) preventive treatment reduces the incidence and the severity of a MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE). IP7e attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process[2].

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