DC_517
CAS No. : 500017-70-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $240 | In-stock |
| 10mg | $401 | In-stock |
| 25mg | $843 | In-stock |
| 50mg | $1333 | In-stock |
| 100mg | $2066 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12747 |
| M.Wt: | 505.65 |
| Formula: | C33H35N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively.
IC50 & Target:IC50: 1.7 μM (DNMT1)[1]
Kd: 0.91 μM (DNMT1)[1]
In Vitro:DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively. DC_517 (1.25, 2.5, 5, and 10 μM) potently inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC_517 (0, 0.75, 1.5, and 3 μM) also dose-dependently induces apoptotic cell death in HCT116 cells[1].
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- Cat. No.:
- HY-12747
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