Chlorantraniliprole

Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC₅₀s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC₅₀, 14 μM). IC50 & Target: EC50: 40 nM (Drosophila melanogaster Ryanodine receptor), 50 nM (H. virescens Ryanodine receptor), 14 μM (Ryanodine receptor, in C2C12 cells) In Vitro: Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor. Chlorantraniliprole actions by release of intracellular Ca²⁺ stores mediated by the ryanodine receptor. Chlorantraniliprole is ∼300-fold less potent against ryanodine receptor (RyRs) in the mouse myoblast cell line, C2C12 (EC₅₀, 14 μM), than in insect RyRs from Drosophila melanogaster and H. virescens (EC₅₀, 40 nM, 50 nM), and shows little selectivity at the rat cell line RyR2 (EC₅₀, >100 μM)^[1]. In Vivo: Chlorantraniliprole has low acute mammalian toxicity with an acute oral LD₅₀ of >5000 mg/kg in rats, and little to no toxicity in 90-day studies, at dosing as high as 1500 mg/kg/day^[1].