(+)-Kavain
CAS No. : 500-64-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $50 | In-stock |
| 25mg | $85 | In-stock |
| 50mg | $125 | In-stock |
| 100mg | $185 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-B1671 |
| M.Wt: | 230.26 |
| Formula: | C14H14O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
(+)-Kavain, a main kavalactone that can be extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels[1]. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy[2]. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied[4].
IC50 & Target:Na+, Ca2+ channel[1].
α4β2δ GABAA receptor[2].
In Vitro:(+)-Kavain (10-300 μM) enhances GABA-elicited responses in a concentration-dependent manner. The modulatory effect of Kavain is moderate, with only 170±23% of enhancement measured at 300 μM[2]. (+)-Kavain inhibits TNF-α secretion in cells via suppression of LITAF[4].
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