5-Chloro-2'-deoxyuridine
CAS No. : 50-90-8
(Synonyms: 5-Chlorodeoxyuridine; CldU)
| Size | Price | Stock |
|---|---|---|
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| 1g | $131 | In-stock |
| 5g | $435 | In-stock |
| 10g | $752 | In-stock |
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| Cat. No. : | HY-112669 |
| M.Wt: | 262.65 |
| Formula: | C9H11ClN2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
5-Chloro-2'-deoxyuridine, a thymine analog, is to study the potential of hypochlorous acid damage to DNA and DNA precursors. In Vitro: When 5-Chloro-2’-deoxyuridine (ClDU) is placed into tissue culture medium, mammalian cells incorporate the analog into DNA. It is observed that 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In the studies reported here, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase[1].
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