Niclosamide (GMP)

Niclosamide (GMP) is Niclosamide (HY-B0497) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research^[1]. Niclosamide is a STAT3 inhibitor with an IC₅₀ of 0.25 μM in HeLa cells^[4]. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells^[2][3][5]. In Vitro: Niclosamide (0.6 nM-46 μM) treatment inhibits adrenocortical carcinoma cellular proliferation in BD140A, SW-13, and NCI-H295R cells^[3].
Niclosamide (0.05-5 μM, 24 h) treatment inhibits STAT3-mediated luciferase reporter activity in HeLa cells ^[4].
Niclosamide (10 μM) inhibits virus replication in Vero E6 cells.

Niclosamide (GMP) (up to 2 μM, 24 h) inhibites Zika virus infection in SNB-19 cells^[6].
Niclosamide (GMP) (1.5 μM，5 d) inhibites nuclear factor‐κB ligand (RANKL)-induced transdifferentiation of macrophages into osteoclast precursors, particularly in the early stage of osteoclastogenesis^[7]. In Vivo: Niclosamide (oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks) treatment inhibits adrenocortical carcinoma tumor growth in vivo^[3].