Estriol
CAS No. : 50-27-1
(Synonyms: Oestriol)
| Size | Price | Stock |
|---|---|---|
| 100mg | $30 | In-stock |
| 500mg | $60 | In-stock |
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| Cat. No. : | HY-B0412 |
| M.Wt: | 288.39 |
| Formula: | C18H24O3 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 80°C);DMSO : 250 mg/mL (ultrasonic) |
Estriol (Oestriol), an orally active estrogen, is a ERα and ERβ agonist. Estriol is a potent GPR30 antagonist in estrogen receptor-negative breast cancer cells. Estriol can ameliorate disease severity through immunomodulatory mechanisms that decrease tissue inflammation. Estriol has powerful proconvulsant effects[1][2][3].
In Vitro:Estriol (Oestriol) binds to both ER and GPR30, however it can exhibit ER agonism or GPR30 antagonism depending on the receptor expression profile in the different cancer cell contexts[1].
Estriol (1-80 μM; for 7 days) reduces cell number of 17β-estradiol stimulated HCC1806 cells very clearly down to 16% at 80 μM[2].
Estriol (100 μM; pretreated for 30 minutes) completely prevented activation of cyclin D1 expression by 17β-estradiol[2].
In Vivo:Estriol (Oestriol ; 0.005, 0.01 mg/kg; IP; daily; for 5 weeks) enhances the percentage incidence of seizures[3].
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