Cortisone acetate
CAS No. : 50-04-4
(Synonyms: Cortisone 21-acetate)
| Size | Price | Stock |
|---|---|---|
| 1g | $25 | In-stock |
| 5g | $60 | In-stock |
| 10g | $100 | In-stock |
| 25g | $200 | In-stock |
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| Cat. No. : | HY-17461A |
| M.Wt: | 402.48 |
| Formula: | C23H30O6 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : 5 mg/mL (ultrasonic) |
Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].
IC50 & Target: Glucocorticoid-receptor[1]
In Vitro: Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs)[1].
In Vivo: Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits[2].
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