Tioxolone
CAS No. : 4991-65-5
| Size | Price | Stock |
|---|---|---|
| 500mg | $11 | In-stock |
| 1g | $19 | In-stock |
| 5g | $37 | In-stock |
| 25g | $113 | In-stock |
| 100g | $330 | In-stock |
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| 500 g | Get quote | |
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| Cat. No. : | HY-B0483 |
| M.Wt: | 168.17 |
| Formula: | C7H4O3S |
| Purity: | >98 % |
| Solubility: | H2O : 0.67 mg/mL (ultrasonic);DMSO : ≥ 100 mg/mL |
Tioxolone is an inhibitor for the carbonic anhydrase. Tioxolone exhibits anti-leishmanial, antitumor, and anti-inflammatory activities. Tioxolone can be used in research of acne and psoriasis[1][2][3].
In Vitro:Tioxolone exhibits anti-leishmanial activity against amastigote and promastigote with IC50s of 49.8 μg/mL and 56.1 μg/mL[2].
Tioxolone (12.5-200 μg/mL, 48 h) dose-dependently induces apoptosis of Leishmania promastigote[2].
Tioxolone (12.5-200 μg/mL, 48 h) increases the expression of IL-12 and metacaspase, decreases the expression of IL-10, exhibiting immunomodulatory effect[2].
Tioxolone (10 µM, 12h) promotes the expression of LC3-II, reduces the expression of p62 protein, and induces autophagy in cancer cell A375[3].
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