Proparacaine
CAS No. : 499-67-2
(Synonyms: Proxymetacaine)
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| Cat. No. : | HY-66012A |
| M.Wt: | 294.40 |
| Formula: | C16H26N2O3 |
| Purity: | >98 % |
| Solubility: |
Proparacaine (Proxymetacaine) is a local anesthetic. Proparacaine blocks voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting signal conduction and nociceptive signal transmission. Proparacaine blocks nociceptive signals in the eye and induces ocular muscle relaxation to reduce eye movement during surgery. Proparacaine is used in research related to cataracts[1][2][3].
In Vitro:Proparacaine competitively inhibits the activity of 6-phosphogluconate dehydrogenase (6PGD) purified from human erythrocytes, with an IC50 of 601.60 μM and a Ki of 811.50 μM[1].
Proparacaine non-competitively inhibits the activity of glutathione reductase (GR) purified from human erythrocytes, with an IC50 of 686.90 μM and a Ki of 1,654.00 μM[1].
Proparacaine alters the actin cytoskeleton of corneal epithelial cells[2].
In Vivo:Proparacaine (proxymetacaine) (0.20-2.92 μmol/kg; s.c.; single injection) induces dose-dependent cutaneous antinociception in rats with an ED50 of 0.57 μmol/kg, and coadministration with Dopamine (HY-B0451) produces a synergistic antinociceptive effect that enhances both the magnitude and duration of block[3].
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