Isomaltose

Isomaltose is a glucose disaccharide. Isomaltose induces G-CSF secretion via heat-induced oxidative polymerization of glucose groups into high-molecular-weight compounds. Isomaltose modulates cecal bacterial cluster structure in mice. Isomaltose exhibits low glycemic index, slow hydrolysis, and prebiotic properties. Isomaltose reduces in vivo Cryptosporidium parvum colonization in neonatal mice. Isomaltose can be used for the research of Cryptosporidium parvum infection^[1][2][3]. In Vitro:Isomaltose (0.4-250 µg/mL; 24 h cell incubation, varied heating conditions) induces G-CSF secretion in MCE301 intestinal epithelial cells via TLR4 activation, with optimal heating conditions at 150°C for 240 min, 180°C for 60 min, or 200°C for 15-30 min, and dose-dependent activity at 0.4-250 µg/mL^[1]. In Vivo:Isomaltose (5 g/10 mL solution; p.o.; single dose) reduces in vivo colonization with Cryptosporidium parvum and induces transient vacuolation of small intestinal epithelial cells in infant BALB/c mice^[3].