AVE-0118
CAS No. : 498577-53-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $114 | In-stock |
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| 10 mg | Get quote | |
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| Cat. No. : | HY-118387 |
| M.Wt: | 479.57 |
| Formula: | C30H29N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AVE-0118 is a nonselective Kv1.5 blocker with an IC50 of 1.1 μM. AVE-0118 is a multichannel inhibitor with weak, micromolar activity against Kv1.5 and other ion channels. It is inactive against IKs, IKATP, and L-type Ca+ channels[1].
IC50 & Target:IC50: 1.1 μM (Kv1.5), 3.4 uM (Ito), 4.5 uM (IKAch), 8.4 uM (IKr)[1]
In Vitro: AVE-0118 is shown to be a Kv1.5 blocker (IC50 = 1.1 uM) with moderate selectivity versus Ito (3.4 uM), IKr (8.4 uM), and IKAch (4.5 uM) and good selectivity versus IKs, IK1, IKATP[1].
AVE-0118 (10 μM) significantly potentiates the electrical field stimulation (EFS)-induced neurogenic type of contractions[2].
In Vivo: AVE-0118 reduces the inducibility of AF in goats with remodeled atria at a dose of 3 mg/kg and did not prolong QTc up to 5 mg/kg[1].
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