Selisistat
CAS No. : 49843-98-3
(Synonyms: EX-527)
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $66 | In-stock |
| 25mg | $121 | In-stock |
| 50mg | $190 | In-stock |
| 100mg | $300 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15452 |
| M.Wt: | 248.71 |
| Formula: | C13H13ClN2O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease[1][2]. IC50 & Target: IC50: 123 nM (SirT1)[2] In Vitro: Selisistat (1-10 μM) inhibits the deacetylation activity of both human SirT1 and Drosophila Sir2 in transfected cells[1]. In Vivo: Selisistat (5 and 20 mg/kg, PO, daily; transgenic R6/2 mice beginning at 4.5 weeksof age to death) is protective in the R6/2 mouse model of Huntington’s disease (HD)[1].
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