Nipecotic acid


CAS No. : 498-95-3

(Synonyms: (±)-β-Homoproline; Hexahydronicotinic acid; 3-Carboxypiperidine)

498-95-3
Price and Availability of CAS No. : 498-95-3
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500g $164 In-stock
1000g $326 In-stock
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Cat. No. : HY-69359
M.Wt: 129.16
Formula: C6H11NO2
Purity: >98 %
Solubility: DMSO : < 1 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic)
Introduction of 498-95-3 :

Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300?μM[1][2]. IC50 & Target: GABA Receptor[1] In Vitro: Nipecotic acid (1?mM) activated inward unitary currents when applied to outside-out patches of paraventricular neurones[1]. In Vivo: Nipecotic acid does not readily cross the blood-brain barrier (BBB)[2].

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