Apocynin


CAS No. : 498-02-2

(Synonyms: Acetovanillone)

498-02-2
Price and Availability of CAS No. : 498-02-2
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Cat. No. : HY-N0088
M.Wt: 166.18
Formula: C9H10O3
Purity: >98 %
Solubility: H2O : 3.33 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : ≥ 100 mg/mL
Introduction of 498-02-2 :

Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[1][2]. Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model[3]. Apocynin can also be used for cancer research[4]. Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass[5]. In Vitro: Apocynin (100 μM; 1-7, 14 days) shows a significant increase in the expression level of an osteogenic marker in the aging BMSCs after osteogenic induction[3].
Apocynin (1, 10, 100 μM, 0-48h ) has selective inhibition the proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells[4].
Apocynin (1, 10, 100 μM; 3, 6, 12 h) decreases the intracellular reactive oxygen species (ROS) level in HR-3Y1-2 but not 3Y1 cells. [4].
In Vivo: Apocynin (0.1 mg/kg/day, i.p., three times per week for 3 months) increases bone mineral density and total bone volume in SAMP6 mice[3].
Apocynin (5 mg/kg, i.p.) reduces the degree of lung injury and attenuates the degree of acute inflammation in the Carrageenan (HY-125474)-induced pleurisy mice[5].

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