Vanillyl alcohol


CAS No. : 498-00-0

(Synonyms: p-(Hydroxymethyl)guaiacol)

498-00-0
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Cat. No. : HY-N2067
M.Wt: 154.16
Formula: C8H10O3
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 498-00-0 :

Vanillyl alcohol (p-(Hydroxymethyl)guaiacol) is an orally active phenolic alcohol. Vanillyl alcohol reduces ROS generation. suppresses Bax, increases Bcl-2. Vanillyl alcohol has anti-angiogenic, anti-inflammatory, anti-nociceptive and neuroprotective effects. Vanillyl alcohol is used as a flavoring agent in foods and beverages[1][2][3]. In Vitro:Vanillyl alcohol (up to 0.5 mM) does not decrease the viability of RAW264.7 cells[2].
Vanillyl alcohol (1-20 μM; 4 h) increases the viability of MPP+-induced MN9D dopaminergic cells[3]. In Vivo:Vanillyl alcohol (3-30 mg/kg; p.o.) inhibits Acetic acid (HY-Y0319)-induced vascular permeability in mice[2].
Vanillyl alcohol (3-30 mg/pouch; administration into the pouch) reduces the exudate volume, the number of polymorphonuclear leukocytes, and the nitrite level in Carrageenan (HY-125474)-induced air pouches in mice[2].
Vanillyl alcohol (3-30 mg/kg; p.o.) inhibits the Acetic acid-induced writhing response in mice[2].

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