TPPB
CAS No. : 497259-23-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $200 | In-stock |
| 5mg | $660 | In-stock |
| 10mg | $1000 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-12359 |
| M.Wt: | 501.54 |
| Formula: | C27H30F3N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
TPPB is a cell-permeable benzolactam-derived protein kinase C (PKC) activator with a Ki of 11.9 nM. IC50 & Target: Ki: 11.9 nM (PKC)[1] In Vitro: By use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB (Compound 5e)[1]. TPPB has a role against Aβ25-35-induced neurotoxicity in PC12 cells. TPPB at concentration of 1 μM could antagonize Aβ25-35 induced cell damage. TPPB could increase the phosphorylation of Akt, PKC, MARCKS and MAPK, which are inhibited by Aβ25-35 treatment. TPPB inhibits the activation of caspase-3 induced by Aβ25-35[2]. In Vivo: TPPB is evaluated for induction of hyperplasia after topical application to the shaved backs of outbred Sencar mice and shows a modest response at 300 μg[1].
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