Arbutin
CAS No. : 497-76-7
(Synonyms: β-Arbutin)
| Size | Price | Stock |
|---|---|---|
| 500mg | $55 | In-stock |
| 5g | $66 | In-stock |
| 10g | $99 | In-stock |
| 25g | $198 | In-stock |
| 50g | $290 | In-stock |
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| Cat. No. : | HY-N0192 |
| M.Wt: | 272.25 |
| Formula: | C12H16O7 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL;H2O : 33.33 mg/mL (ultrasonic) |
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3]. IC50 & Target:Tyrosinase[1] In Vitro:Arbutin (0.3-5.4 mM; 24 hours, 48 hours, 72 hours; B16 murine melanoma cells) inhibites the viability of B16 murine melanoma cells in a time-and dose-dependent manner[2].
Arbutin (1.4-5.4 mM; 24 hours) increases the apoptosis rate of B16 murine melanoma cell of treatment at a dose of 5.4 mM[2]. In Vivo:Arbutin (50 mg/kg, 100 mg/kg; oral administration; every day; for 17 days; male C57BL/6 mice) pretreatment exhibits markedly protective effects on ISO-induced cardiac hypertrophy in mice[3].
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