Ergothioneine
CAS No. : 497-30-3
(Synonyms: L-(+)-Ergothioneine)
| Size | Price | Stock |
|---|---|---|
| 5mg | $61 | In-stock |
| 10mg | $95 | In-stock |
| 25mg | $190 | In-stock |
| 50mg | $365 | In-stock |
| 100mg | $511 | In-stock |
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| Cat. No. : | HY-N1914 |
| M.Wt: | 229.31 |
| Formula: | C9H15N3O2S |
| Purity: | >98 % |
| Solubility: | H2O : 125 mg/mL (ultrasonic) |
Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt, which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity[1][2].
In Vitro:Ergothioneine (0.25, 1 mM, 23 h) can regulate PC12 DNA damage, MAPKs activation and cell death induced by hydrogen peroxide[1].
In Vivo:Ergothioneine (70 mg/kg orally, For 14 consecutive days) mediates the improvement of cisplatin-induced nephrotoxicity in rats by regulating Nrf2, p53 and NF-κB signaling and inhibiting γ-glutamyltranspeptidase[2].
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