EN460
CAS No. : 496807-64-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $168 | In-stock |
| 25mg | $285 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $620 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12837 |
| M.Wt: | 460.79 |
| Formula: | C22H12ClF3N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C) |
EN460 is a selective endoplasmic reticulum oxidation 1 (ERO1) inhibitor. EN460 (IC50 of 1.9 μM) interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation[1]. In Vitro: Exposure of cells to EN460 or QM295 resulted in the accumulation of an ERO1α form with lower mobility, indicative of the reduced state. EN460 and QM295 were also found to activate an unfolded protein response reporter in cultured 293T cells[1].
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