Tetraethylenepentamine (pentahydrochloride)

Tetraethylenepentamine pentahydrochloride is an orally active copper chelator and copper mobilizer. Tetraethylenepentamine pentahydrochloride exhibits growth inhibitory and hypolipidemic properties. Tetraethylenepentamine pentahydrochloride significantly increases urinary copper excretion and reduces renal copper accumulation in copper overload models, but does not significantly alter hepatic copper levels. Tetraethylenepentamine pentahydrochloride exerts growth inhibitory effects on Candida albicans and Fluconazole (HY-B0101)-resistant strains, and can be widely used in studies related to Wilson's disease and Candida infections^[1][2]. In Vitro:Tetraethylenepentamine pentahydrochloride (10 μM; 24 h) inhibits growth of Candida albicans ATCC 90028 and Fluconazole (HY-B0101)-resistant Candida albicans strain Q181103513 by 94%^[2]. In Vivo:Tetraethylenepentamine pentahydrochloride (TETREN) (0.67 mmol/kg/d; p.o.; twice daily; 5 days) is the most effective chelator tested, inducing an 18-fold increase in urinary copper excretion, significantly reducing fecal copper excretion and renal copper levels by 50% in copper-overloaded rats, without significantly lowering hepatic copper levels^[1].
Co-administration of tetraethylenepentamine pentahydrochloride (TETREN) (0.67 mmol/kg/d; p.o.; twice daily; 5 days) and zinc acetate (2.5 mg Zn/kg/d; p.o.; daily; 5 days) induces a 14-fold increase in urinary copper excretion, significantly reducing fecal copper excretion and renal copper levels in copper-overloaded rats, with efficacy slightly lower than TETREN alone^[1].