Glycyl-L-histidyl-L-lysine


CAS No. : 49557-75-7

(Synonyms: GHK; Tripeptide-1)

49557-75-7
Price and Availability of CAS No. : 49557-75-7
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Cat. No. : HY-P0046
M.Wt: 340.38
Formula: C14H24N6O4
Purity: >98 %
Solubility: H2O : 100 mg/mL (ultrasonic)
Introduction of 49557-75-7 :

Glycyl-L-histidyl-L-lysine is a tripeptide consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance[1][2][3]. In Vitro:Glycyl-L-histidyl-L-lysine and its copper complexes and saccharomyces/copper ferment on secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line[1].
Glycyl-L-histidyl-L-lysine and its copper complexes decreases TNF-α-dependent IL-6 secretion in fibroblasts[1]. In Vivo:Glycyl-L-histidyl-L-lysine (intraperitoneal injection; 1.5, 5, 50, 150, and 450 mg/kg; 10 times ) can stimulate mitotic activity of hepatocytes and dose-dependently suppresse immune reactivity[2].
Glycyl-L-histidyl-L-lysine (intraperitoneal injection; 0.5, 5, and 50 μg/kg) can produce an anxiolytic effect in the elevated plus maze test[3].

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