TCS PIM-1 1
CAS No. : 491871-58-0
(Synonyms: SC 204330)
| Size | Price | Stock |
|---|---|---|
| 5mg | $83 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $245 | In-stock |
| 50mg | $363 | In-stock |
| 100mg | $540 | In-stock |
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| Cat. No. : | HY-18086 |
| M.Wt: | 367.20 |
| Formula: | C18H11BrN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitive Pim-1 kianse inhibitor with an IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s >20000 nM)[1]. IC50 & Target: IC50: 50 nM (Pim-1)[1] In Vitro: TCS PIM-1 1 (compound 1), a substituted pyridone scaffold, binds convincingly within the ATP-binding site of Pim-1 suggesting an ATP-competitive inhibitory mechanism. Preliminary data further suggests that TCS PIM-1 1 lacked in vitro inhibitory activity toward related serine/threonine kinases Pim-2 and MEK1/2. Hence, small molecules similar to TCS PIM-1 1 may serve as useful starting scaffolds for the development of other improved yet selective Pim-1 inhibitors. TCS PIM-1 1 serves both as a starting point for SAR chemical syntheses and was used for co-crystallization with Pim-1 protein[1].
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