2,5-Dihydroxyacetophenone
CAS No. : 490-78-8
| Size | Price | Stock |
|---|---|---|
| 10g | $8 | In-stock |
| 25g | $11 | In-stock |
| 100g | $38 | In-stock |
| 500g | $156 | In-stock |
| 1000g | $311 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-W001174 |
| M.Wt: | 152.15 |
| Formula: | C8H8O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways[1]. In Vitro: 2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells[1].
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