Limocitrin
CAS No. : 489-33-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $378 | In-stock |
| 5mg | $944 | In-stock |
| 10mg | $1510 | In-stock |
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| Cat. No. : | HY-119539 |
| M.Wt: | 346.29 |
| Formula: | C17H14O8 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Limocitrin is a flavonol glycoside. Limocitrin inhibits AKT phosphorylation and JNK phosphorylation, upregulates p38 phosphorylation, and inhibits ERK1/2 phosphorylation, thereby blocking MAPK signaling. Limocitrin induces Apoptosis through the mitochondrial pathway, death receptor-mediated signaling, Caspase activation, and G2/M cell cycle arrest. Limocitrin possesses anti-inflammatory and anticancer properties. Limocitrin can be used for research on oral squamous cell carcinoma and chronic myeloid leukemia[1][2].
In Vitro:Limocitrin (0-40 µM; 24-72 h) significantly inhibits the viability of SCC-9 and SCC-47 oral cancer cells in a concentration- and time-dependent manner, with SCC-9 cells exhibiting higher sensitivity[1].
Limocitrin (0-40 µM; 24 h) exerts a strong antiproliferative effect on SCC-9 and SCC-47 oral cancer cells by reducing colony formation[1].
Limocitrin (5-20 μM; 72 h) enhances the cytotoxicity of KHYG-1 cells against K562 cells[2].
Limocitrin (24 h) induces apoptosis in oral cancer cells through the mitochondrial pathway, manifested by a decrease in mitochondrial membrane potential[1].
Limocitrin (0-40 µM; 24 h) induces apoptosis in SCC-9 and SCC-47 oral cancer cells by modulating the expression of Bcl-2 family proteins and death receptor-related proteins[1].
Limocitrin (0-40 µM; 24 h) induces G2/M phase arrest in SCC-9 and SCC-47 oral cancer cells by downregulating cyclin E1, E2, CDK2, CDK4, and CDK6, and upregulating p21[1].
Limocitrin (24 h) inhibits the AKT/ERK/JNK signaling pathways and activates p38 in SCC-9 and SCC-47 oral cancer cells[1].
Limocitrin (5-20 μM; 24 h) increases the protein expression of cytolytic effector molecules perforin, granzyme A and B, and granulysin in KHYG-1 cells[2].
Limocitrin (5-20 μM; 24 h) dose-dependently increases CREB phosphorylation and histone H3 acetylation in KHYG-1 cells[2].
Limocitrin (5-20 μM; 24 h) dose-dependently increases mitochondrial membrane depolarization in K562 cells co-cultured with KHYG-1 cells[2].
Limocitrin (5-20 μM) increases apoptosis of K562 cells co-cultured with KHYG-1 cells[2].
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