Vinburnine
CAS No. : 4880-88-0
(Synonyms: (-)-Eburnamonine; (-)-Vincamone)
| Size | Price | Stock |
|---|---|---|
| 100mg | $70 | In-stock |
| 250mg | $129 | In-stock |
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| 1 g | Get quote | |
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| Cat. No. : | HY-B1180 |
| M.Wt: | 294.40 |
| Formula: | C19H22N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 8.33 mg/mL (ultrasonic) |
Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.
In Vitro:Vinburnine is the allosteric modulator of muscarinic receptors M1-M4, decelerates the binding of [H]N-methylscopolamine to muscarinic M1-M4 receptors in CHO cell with EC50s of 29.5, 4.1, 9.5, and 15.0 μM, respectively[3].
In Vivo:Vinburnine (5-50 mg/kg, ip, single dose) exhibits anti-amnesia effect in Scopolamine (HY-N0296)-induced mouse amnesia model[2].
Vinburnine promotes erythrocyte glycolysis, increases erythrocyte ATP and 2,3-diphosphoglycerol content, improves erythrocyte deformability and tissue oxygen delivery[3].
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