MAC13772
CAS No. : 4871-40-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $270 | In-stock |
| 100mg | $450 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-116872 |
| M.Wt: | 227.24 |
| Formula: | C8H9N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 17.86 mg/mL (ultrasonic) |
MAC13772 is a BioA inhibitor with an IC50 of 0.28 μM against E. coli and an IC50 of 0.269 μM against A. baumannii. MAC13772 inhibits bacterial growth by targeting the biotin biosynthesis pathway. MAC13772 can be used in studies related to bacterial infections[1][2].
In Vitro:MAC13772 inhibits the purified E. coli BioA enzyme with an IC50 of 0.28 μM[1].
MAC13772 inhibits purified A. baumannii BioA enzyme with an IC50 value of 0.269 μM[1].
MAC13772 inhibits the growth of E. coli BW25113 WT and A. baumannii ATCC 17978 WT in biotin-free minimal medium, with an MIC of 8 μg/mL for both strains, and this activity is reversible by biotin supplementation[1].
MAC13772 (0.01-100 μM; 20 days) inhibits the growth of Phaeodactylum tricornutum by targeting biotin synthesis, reduces the level of protein biotinylation, and exogenous biotin supplementation can partially restore its growth[2].
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