Indican
CAS No. : 487-60-5
(Synonyms: Indoxyl-β-D-glucoside)
| Size | Price | Stock |
|---|---|---|
| 250mg | $99 | In-stock |
| 1g | $305 | In-stock |
| 5g | $1480 | In-stock |
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| Cat. No. : | HY-122009 |
| M.Wt: | 295.29 |
| Formula: | C14H17NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);Methanol : 83.33 mg/mL (ultrasonic);H2O : 20 mg/mL (ultrasonic) |
Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4[1][2]. In Vivo: Indican ((Indoxyl-β-D-glucoside; oral; 20, 40 mg/kg; single dose) increases the systemic exposure and MRT of MTX through inhibition on multiple anion transporters including OAT 1, OAT 3 and MRP 4 by the major metabolite IS[1].
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