Hypaphorine
CAS No. : 487-58-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $80 | In-stock |
| 5mg | $220 | In-stock |
| 10mg | $330 | In-stock |
| 25mg | $600 | In-stock |
| 50mg | $900 | In-stock |
| 100mg | $1350 | In-stock |
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| Cat. No. : | HY-N2179 |
| M.Wt: | 246.31 |
| Formula: | C14H18N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 100 mg/mL (ultrasonic) |
Hypaphorine is an indole found in Caragana korshinskii. Hypaphorine has neurological and glucose-lowering effects. Hypaphorine prevents Lipopolysaccharides (LPS) (HY-D1056)-mediated acute lung injury (ALI) and proinflammatory response via inactivating the p38/JNK signaling pathway by upregulating DUSP1[1][2][3][4].
In Vitro:Hypaphorine (6.25-100 μM, 24 h) inhibits the Lipopolysaccharides (LPS) (HY-D1056)-mediated apoptosis of alveolar epithelial cells[2].
Hypaphorine (12.5-50 μM, 48 h) attenuates the expression of inflammatory factors (IL-1β, IL-6, TNF-α, and IL-18) and inactivates the p38/JNK signaling pathway through up-regulating DUSP1 in a dose-dependent manner[2].
Hypaphorine reverses inhibition of E. globulus seedling root growth induced by 3-Indoleacetic acid (Indole-3-acetic acid) (HY-18569)[3].
In Vivo:Hypaphorine (10 mg/kg; i.p.; 2 hours after the LPS injection) relieves LPS induced acute lung injury (ALI) in rats with anti-inflammatory effects[2].
Hypaphorine (50 mg/kg; i.p.; once) has antihyperglycemic activity[4].
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