Flavanone
CAS No. : 487-26-3
| Size | Price | Stock |
|---|---|---|
| 100mg | $15 | In-stock |
| 5g | $18 | In-stock |
| 10g | $29 | In-stock |
| 25g | $56 | In-stock |
| 100g | $194 | In-stock |
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| Cat. No. : | HY-N7128 |
| M.Wt: | 224.26 |
| Formula: | C15H12O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Flavanone is a naturally occurring flavone. Flavanone has inhibitory activity for human estrogen synthetase (aromatase). Flavanone is the inhibitor for ERK/p38/NF-κB signaling pathway. Flavanone exhibits oral activity and antitumor efficacy[1][2].
In Vitro:Flavanone (0-100 μM, 48 h) inhibits the cell proliferation, migration and invasion of A549, arrests cell cycle at G1 phase[2][3].
Flavanone (0-100 μM, 48 h) inhibits the expression of MMP-2, u-PA, cyclin D1 and CDK2, promotes the generation of TIMP-2 (MMP-2 inhibitor) and PAI-1 (u-PA inhibitor)[2][3].
In Vivo:Flavanone (100 mg/kg, po, once a day for 29 days) exhibits antitumor efficacy in C57BL/6J mouse models[2][3].
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