Citropten

Citropten (5, 7-dimethoxycoumarin) is one of the coumarin derivatives. Citropten is an effective oral anticancer agent. Citropten has anti-proliferative activity against A2058 and B16 melanoma cells. Citropten exerts anti-inflammatory effects through the NFκB and MAPK signaling pathways. Citropten acts as an antidepressant through heat shock protein-70, monoamine oxidase-A and inhibition of apoptosis^{[1] [2] [3]}. In Vitro: Citropten (10-500 mM; 72 h) inhibits the proliferation in A2058 human melanoma cell line^[1].
Citropten (0-40 μM; 24 h) reduces NFκB and MAPK signaling pathway in activated Jurkat and HT-29 cells^[2]. In Vivo: Citropten (10 mg/kg; Oral administration; Every day; 7 days) has anti-inflammatory effects and modulates T cell and intestinal epithelial cell activity in mouse models of colitis induced by DSS (HY-116282)^[2].
Citropten (10 mg/kg; Intraperitoneal injection; Single injection) exerts an antidepressant effect by increasing the level of heat shock protein-70 and inhibiting the level of monoamine oxidase-A in rat models of chronic mild stress depression^[3].