Anagyrine
CAS No. : 486-89-5
(Synonyms: (-)-Anagyrine; Monolupine; Rhombinine)
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| Cat. No. : | HY-121027 |
| M.Wt: | 244.33 |
| Formula: | C15H20N2O |
| Purity: | >98 % |
| Solubility: | H2O : 25 mg/mL (ultrasonic);DMSO : 25 mg/mL (ultrasonic) |
Anagyrine ((-)-Anagyrine) is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine is a potent and effective desensitizer of nAChR, and Anagyrine can directly, without metabolism, desensitize nAChR[1][2][3]. In Vitro:Anagyrine acts as a partial agonist in both cell lines with EC50 values of 4.2 and 231 μM in SH-SY5Y and TE-671 cells, respectively. Anagyrine is a desensitizer of nAChR with DC50 values of 6.9 and 139 μM in SH-SY5Y and TE-671 cells, respectively[3].
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