N-Methylcytisine
CAS No. : 486-86-2
(Synonyms: Caulophylline)
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $95 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $290 | In-stock |
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| Cat. No. : | HY-N0443 |
| M.Wt: | 204.27 |
| Formula: | C12H16N2O |
| Purity: | >98 % |
| Solubility: |
N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia[1][2].
IC50 & Target:kd: 50 nM (nicotinic acetylcholine receptors)[2]
In Vivo:N-Methylcytisine (Compound NMC) (4-16 mg/kg, i.g., once per day) ameliorates the symptoms of DSS-induced colitis in mouse model[1].
N-Methylcytisine (16 mg/kg, p.o., once per day) significantly reduces the concentrations of TNF-α, IL-1β, and IL-6 as well as inhibiting the expression of p-NK-κB p65 in the colon tissue of mice[1].
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