Vasicinone
CAS No. : 486-64-6
(Synonyms: (-)-Vasicinone)
| Size | Price | Stock |
|---|---|---|
| 1mg | $60 | In-stock |
| 5mg | $210 | In-stock |
| 10mg | $340 | In-stock |
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| Cat. No. : | HY-N1100 |
| M.Wt: | 202.21 |
| Formula: | C11H10N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1].
In Vitro: Vasicinone (1~30 µM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability[1].
Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death[1].
Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins[1].
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