Ononin (Standard)

Ononin (Standard) is the analytical standard of Ononin. Ononin is an orally active isoflavone. Ononin inhibits the ERK/JNK/p38 and PI3K/Akt/mTOR pathways. Ononin regulates Apoptosis. Ononin has anti-tumor effects on laryngeal cancer and lung cancer. Ononin has neuroprotective effects. Ononin alleviates endoplasmic reticulum stress and diabetic nephropathy^{[1][2][3][4][5][6]}. In Vitro:Ononin (10-100 μM, 24 h) shows anticancer activity against laryngeal cancer Hep-2 cells via the inhibition of ERK/JNK/p38 signaling pathway^[1].
Ononin (6.25-100 μM, 48 h) shows anticancer activity against human HepG2 cells, with IC₅₀ of 40.8 μM^[2].
Ononin (3-10  μM) exerts antitumor effects against lung cancer cells A549 and HCC827 by regulating apoptosis through inhibiting the PI3K/Akt/mTOR pathway^[3].
In Vivo:Ononin (30 mg/kg, p.o., 12 days) shows neuroprotective effects against aluminium chloride-induced Alzheimer’s disease in rats^[4].
Ononin (10-50 mg/kg, p.o., once a day for 60 days) mitigates Streptozotocin (HY-13753)-induced diabetic nephropathy in rats via alleviating oxidative stress and inflammatory markers^[5].
Ononin (30-60 mg/kg/day, gavage, 8 weeks) alleviates endoplasmic reticulum stress in Doxorubicin (HY-15142A)-induced cardiotoxicity in rats by activating SIRT3^[6].