Bergaptol
CAS No. : 486-60-2
(Synonyms: 5-Hydroxypsoralen; 4-Hydroxybergapten)
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $35 | In-stock |
| 25mg | $50 | In-stock |
| 50mg | $75 | In-stock |
| 100mg | $120 | In-stock |
| 500mg | $264 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-76316 |
| M.Wt: | 202.16 |
| Formula: | C11H6O4 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic);DMSO : ≥ 50 mg/mL |
Bergaptol is an inhibitor of debenzylation of the CYP3A4 enzyme with an IC50 of 24.92 μM. Recent studies have shown that it has anti-proliferative and anti-cancer properties[1].
In Vitro: Bergaptol (0-800 ppm) shows free radical scavenging activity, tested by ABTS and DPPH methods[1].
Bergaptol (50 μg/mL, 24 h) inhibits LPS-induced production of NO, IL-6, and TNF-α in RAW264.7 cells[3].
Bergaptol (50 μg/mL, 24 h) inhibits LPS-induced MAPK phosphorylation and nuclear factor-kappa B (NF-κB) activation in RAW264.7 cells[3].
In Vivo: Bergaptol (10-40 mg/kg, i.p., once a day for two weeks) improves the cognitive impairment in LPS-treated mice[4].
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