Coclaurine
CAS No. : 486-39-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $125 | In-stock |
| 5mg | $350 | In-stock |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-N3610 |
| M.Wt: | 285.34 |
| Formula: | C17H19NO3 |
| Purity: | >98 % |
| Solubility: |
Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum with anticancer activity. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist. Coclaurine is a key molecule in S. tetrandra responsible for EFHD2 inhibition. Coclaurine can downregulate EFHD2-related NOX4-ABCC1 signaling and enhanced Cisplatin (HY-17394) sensitivity. Coclaurine suppresses the stemness and metastatic properties of NSCLC cells. Coclaurine disrupts the interaction between the transcription factor FOXG1 and the EFHD2 promoter, leading to a reduction in EFHD2 transcription[1][2][3][4].
In Vitro: Coclaurine (200 μM) significantly sensitizes NSCLC cells to Cisplatin in A549 cells[4].
Coclaurine (0-200 μM) decreases the spheroid formation in NSCLC cells[4].
Coclaurine (200 μM) decreases FOXG1 protein thermal stability in H1299 cells[4].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Coclaurine
- Cat. No.:
- HY-N3610
- Quantity:
Your information is safe with us.