Isofraxidin
CAS No. : 486-21-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $28 | In-stock |
| 5mg | $50 | In-stock |
| 10mg | $70 | In-stock |
| 20mg | $98 | In-stock |
| 50mg | $157 | In-stock |
| 100mg | $220 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N0774 |
| M.Wt: | 222.19 |
| Formula: | C11H10O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits MMP-7 expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells[1]. Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation[2].
In Vitro: Isofraxidin inhibits expression of MMP-7 and in vitro cell invasion at a non-toxic level through inhibiting ERK1/2 phosphorylation in hepatoma cell lines[1].
Isofraxidin competitively inhibits TLR4/MD-2 complex formation, and thus TLR4/NF-κB signalling cascades.Isofraxidin has potential in the treatment of Osteoarthritis (OA)[2].
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