Cytisinicline
CAS No. : 485-35-8
(Synonyms: Cytisine; Sophorine; Baptitoxine)
| Size | Price | Stock |
|---|---|---|
| 250mg | $11 | In-stock |
| 1g | $38 | In-stock |
| 5g | $75 | In-stock |
| 10g | $120 | In-stock |
| 25g | $220 | In-stock |
| 100g | $720 | In-stock |
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| Cat. No. : | HY-N0175 |
| M.Wt: | 190.25 |
| Formula: | C11H14N2O |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 100 mg/mL;DMSO : 125 mg/mL (ultrasonic) |
Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. Has been used medically to help with smoking cessation[3].
IC50 & Target:α4β2 nAChRs[1].
In Vitro: Cytisinicline (Cytisine) (2.5, 5 and 10 mM) is capable of inducing apoptosis in HepG2 cells[4].
Treatment with Cytisinicline (Cytisine) increases the percentage of cells in the sub-G1 phase (P<0.01). The preincubation of HepG2 cells with Cytisinicline (Cytisine) (2.5, 5 and 10 mM) significantly increases the sub-G1 cell population[4].
In Vivo: Cytisinicline (Cytisine) (5 mg/kg, i.p.) eat less and gain less weight than those that receive the vehicle[2].
Total pellet intake increases during Cytisinicline (Cytisine) substitution relative to nicotine and animals self-administered Cytisine significantly less than nicotine[2].
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