N-Nornuciferine
CAS No. : 4846-19-9
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|---|---|---|
| 5mg | $210 | In-stock |
| 10mg | $360 | In-stock |
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| Cat. No. : | HY-N2129 |
| M.Wt: | 281.35 |
| Formula: | C18H19NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
N-Nornuciferine is an orally active, blood-brain barrier-permeable CYP2D6 inhibitor, with an IC50 of 3.76 μM and a Ki of 2.34 μM against human CYP2D6. N-Nornuciferine also acts as a BChE inhibitor, showing an IC50 of 5.6 μM in mice. N-Nornuciferine can be used in the research of neurological-related diseases[1][2][3]. IC50 & Target:IC50: 3.76 μM (CYP2D6)[1]
Ki: 2.34 μM (CYP2D6)[1]
In Vitro:N-nornuciferine potently inhibits CYP2D6 in pooled human liver microsomes via competitive inhibition (IC50 = 3.76 μM, Ki = 2.34 μM), while it only exerts weak inhibitory effects on CYP2C19 (IC50 = 29 μM)[1].N-Nornuciferine (Compound 5) is a BChE inhibitor with an IC50 of 5.6 μM in mice[3].
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