DPH


CAS No. : 484049-04-9

484049-04-9
Price and Availability of CAS No. : 484049-04-9
Size Price Stock
5mg $86 In-stock
10mg $138 In-stock
25mg $300 In-stock
50mg $490 In-stock
100mg $730 In-stock
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Cat. No. : HY-12070
M.Wt: 336.32
Formula: C18H13FN4O2
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 484049-04-9 :

DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.   In Vitro: DPH binds to the myristoyl binding site and prevents the formation of the bent conformation of the αI helix through steric hindrance, a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site. DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation[1].

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