β-Glucuronidase-IN-1
CAS No. : 484006-66-8
| Size | Price | Stock |
|---|---|---|
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| 10mg | $170 | In-stock |
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| Cat. No. : | HY-103081 |
| M.Wt: | 425.54 |
| Formula: | C23H27N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC50 and a Ki of 283 nM and 164 nM, respectively[1]. IC50 & Target: IC50: 283 nM (E. coli β-glucuronidase)Ki: 164 nM (E. coli β-glucuronidase)[1] In Vitro: β-Glucuronidase-IN-1 (Inhibitor 1) (0.01-100 μM) inhibits E. coli β-glucuronidase activity as a dose-dependent manner and exhibits an IC50 and a Ki value with 283 nM and 164 nM, respectively[1].β-Glucuronidase-IN-1 (100 μM; 24-72 hours) maintains potent efficacy in living bacterial cells (EC50=17.7 nM), it does not affect bacterial cell growth under aerobic or anaerobic conditions or killing mammalian epithelial cells[1]. In Vivo: β-Glucuronidase-IN-1 (oral gavage; 10 μg; twice per day; 11 days) protects the mouse GI epithelium from CPT-11-induced damage and protects the glandular structure of CPT-11-treated intestinal tissues[1].
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