Dictamine


CAS No. : 484-29-7

(Synonyms: Dictamnine; Dectamine)

484-29-7
Price and Availability of CAS No. : 484-29-7
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1mg $23 In-stock
5mg $50 In-stock
10mg $70 In-stock
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Cat. No. : HY-N0849
M.Wt: 199.21
Formula: C12H9NO2
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic)
Introduction of 484-29-7 :

Dictamnine (Dictamine) exhibits cytotoxicity to human cervical and colon cancer cells and also has antibacterial and antifungal activities[1]. In Vitro: Dictamine shows antimicrobial activity against Saccharomyces cerevisiae (MIC: 64 μg/mL)[1].
Dictamine (2 μg/mL, 24 h) reduces ROS and mitochondrial ROS, and reduces IL-1β, TNF-α expression in HaCaT inflammation model[2].
Dictamine (0-100 μM, 12 h) inhibits cell proliferation, migration and invasion, and induces apoptosis in HCT116 cells, by downregulating HIF-1α and Slug. I[3].
In Vivo: Dictamine (2 μg/mL, 200 μL, applied once daily, for 14 days) reduces skin inflammation and skin swellingin Oxazolone (HY-126360)-induced atopic dermatitis mice model[2].
Dictamine (50 and 100 mg/kg, p.o., three times a week) inhibits tumor growth in a HCT116 xenograft tumor model[3].
Dictamine (1 and 5 mg/kg, 200 μL, applied to the skin) ameliorates chronic itch in 2,4-dinitrofluorobenzene-induced atopic dermatitis mice[4].

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