Kokusaginine
CAS No. : 484-08-2
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| Cat. No. : | HY-114803 |
| M.Wt: | 259.26 |
| Formula: | C14H13NO4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Kokusaginine is a furoquinoline alkaloids, which exhibits inhibitory efficacy for acetylcholinesterase (AChE) with an IC50 of 28.2 μM. Kokusaginine exhibits anti-proliferative and apoptotic inducing effects in MCF-7/ADR cells[1][2].
In Vitro:Kokusaginine (0-30 μM) inhibits proliferations of cells MCF-7, MDA-MB-231 and their multidrug resistant sublines MCF-7/ADR, MDA-MB-231/ADR, with IC50s of 7.23, 4.62, 9.01 and 10.19 μM through inhibition of tubulin polymerization[2].
Kokusaginine (6-24 μM) induces apoptosis in cells MCF-7 and MCF-7/ADR in a dose-dependent manner[2].
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