Purmorphamine
CAS No. : 483367-10-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $99 | In-stock |
| 10mg | $135 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $340 | In-stock |
| 100mg | $540 | In-stock |
| 250mg | $1080 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-15108 |
| M.Wt: | 520.62 |
| Formula: | C31H32N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM. IC50 & Target: IC50: 1.5 μM (Smoothened) In Vitro: Purmorphamine (10, 20 μM) in combination with sirolimus significantly decreases cell numbers according to the MTT assay. Purmorphamine induces up-regulation of alkaline phosphatase activity and expression of RUNX-2 at day 14. Up-regulation of osteocalcin is detected at the 3 and 5 μM doses of purmorphamine on day 14 post-induction. Matrix mineralization remains unchanged in the presence or absence of purmorphamine[1]. Purmorphamine induces STAT3 phosphorylation in mouse ES cell line ES14 and mesenchymal stem cell line C3H10T1/2[2]. Purmorphamine up-regulates the expressionof markers of the osteoblast phenotype-ALP activity and bone-like nodule formationd-in human bonemarrow mesenchymal cells[3].
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