A-286501
CAS No. : 483341-15-7
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| Cat. No. : | HY-116005 |
| M.Wt: | 328.17 |
| Formula: | C11H14BrN5O2 |
| Purity: | >98 % |
| Solubility: |
A-286501 is an orally active and potent carbocyclic nucleoside adenosine kinase inhibitor with an IC50 value of 0.47 nM, which shows analgesic and anti-inflammatory effects. A-286501 reduces nociception in animal models of acute (thermal), inflammatory (formalin and carrageenan) and neuropathic (L5/L6 nerve ligation and streptozotocin-induced diabetic) pain. A-286501 also reduces Carrageenan (HY-125474)-induced paw edema and myeloperoxidase activity in the injured paw. A-286501 is promising for research of analgesic and anti-inflammatory agents[1].
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