Crotamiton
CAS No. : 483-63-6
| Size | Price | Stock |
|---|---|---|
| 100g | $71 | Get quote |
| 500g | $247 | Get quote |
| 1 kg | Get quote | |
| 2 kg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-B1177 |
| M.Wt: | 203.28 |
| Formula: | C13H17NO |
| Purity: | >98 % |
| Solubility: | DMSO : 140 mg/mL (ultrasonic);H2O : 140 mg/mL (ultrasonic) |
Crotamiton is a TRPV4 inhibitor. Crotamiton inhibits TRPV4 currents. Crotamiton inhibits TRPV4 selective agonist-induced pruritus-related behaviors in mice. Crotamiton inhibits Histamine- and Chloroquine-induced calcium influx via the H1R/TRPV1, MRGPRA3/TRPA1 pathways, and also suppresses calcium influx in primary mouse dorsal root ganglion neurons. Crotamiton is applicable to research related to pruritus, scabies, and non-scabietic pruritus[1][2].
In Vitro:Crotamiton (0-500 μM) potently inhibits GSK1016790A-activated mTRPV4 currents in HEK293T cells under the condition of 2 mM extracellular Ca2+ in vitro, with IC50 values of 15.5 μM and 16.3 μM in mouse and human, respectively[1].
Crotamiton (100-1000 μM) inhibits mTRPV4 currents activated by GSK1016790A in HEK293T cells cultured in calcium-free medium, with an IC50 of 223.5 μM[1].
Crotamiton (0-1000 μM) inhibits TRPV4 currents in GSK1016790A-activated NHEK cells in calcium-free medium[1].
Crotamiton (0-1000 μM) reduces the open probability and unitary amplitude of mTRPV4 single channels in HEK293T cells[1].
Washout after co-treatment with Crotamiton (0-1000 μM; 60 s, co-applied with GSK1016790A) and GSK1016790A induces dilation of the mTRPV4 channel in HEK293T cells, which allows the permeation of large cations up to TetMA+ (6.48 Å diameter), but does not permit the permeation of NMDG (8.90 Å diameter)[1].
Crotamiton (1 mM; 5 min pre-incubation) inhibits histamine (HY-B1204)- and chloroquine (HY-17589A)-induced calcium influx in HEK293T cells expressing H1R/TRPV1 or MRGPRA3/TRPA1, with IC50 values of 101.2 μM and 326.2 μM, respectively. Its mechanism of action functions through the H1R/TRPV1 pathway, rather than directly inhibiting TRPV1[2].
In Vivo:Topical administration of a single dose of Crotamiton (30 μL) significantly inhibits TRPV4 agonist (GSK1016790A) (HY-19608)-induced pruritus-related scratching behavior in C57BL/6N mice[1].
Crotamiton (i.p., 125 mg/kg, single dose) reduces histamine- and chloroquine-induced scratching episodes in male ICR mice[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Crotamiton
- Cat. No.:
- HY-B1177
- Quantity:
Your information is safe with us.