Ajmalicine
CAS No. : 483-04-5
(Synonyms: Raubasine)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $256 | In-stock |
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| Cat. No. : | HY-N1919 |
| M.Wt: | 352.43 |
| Formula: | C21H24N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 5.56 mg/mL (ultrasonic;warming;heat to 60°C) |
Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity[1][2].
IC50 & Target: IC50: 72.3 μM (nicotine receptor)[2]
In Vitro: Ajmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor[1].
Ajmalicine inhibits contractions in a concentration-dependent manner (IC50=72.3 ± 22.5 μM)[2].
Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[3].
In Vivo: Ajmalicine blocking the pressor action of electrical stimulation and is active against sympathetic stimulation[1].
Ajmalicine (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline[1].
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