Estrone sulfate

Estrone sulfate is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate is also a substrate of the OATP1B3 transporter. Estrone sulfate can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate is applicable to breast cancer-related research^[1][2][3][4]. In Vitro:Estrone sulfate (1.0 μM; 1-64 min) is taken up at a low rate by dispersed normal breast parenchymal cells, resulting in a cells/medium concentration ratio of 0.20-0.33 when incubated at 37°C^[2].
Estrone sulfate (1.0 nM-100 μM) is converted to estrone by dispersed normal breast parenchymal cells with a mean half-time of 628 min per 10⁶ cells (intact cells) or 246 min per 10⁶ cells (homogenized cells)^[2].
Estrone sulfate is not produced via conversion of estrone by dispersed normal breast parenchymal cells under conditions where MCF-7 breast cancer cells exhibit sulfotransferase activity^[2].
Estrone sulfate stimulates colony formation in dispersed nitrosomethylurea mammary cells and is converted to estrone and estradiol by these cells^[3]. In Vivo:Estrone sulfate (30-3000 pmol/hr; 400-1300 pmol/hr; s.c.; continuous infusion; 14 days) exerts dose-related stimulatory effects on nitrosomethylurea-induced hormone-responsive mammary tumor growth in castrate rats, with significant conversion to estrone and estradiol^[3].
Estrone sulfate (75 mg/kg; p.o; daily; for 5 days) reduces glucose-6-phosphatase activity and protein levels, and lowers blood glucose in ob/ob mice^[4].
Estrone sulfate modulates glucose-6-phosphatase kinetic parameters in control mice^[4].