Aloe emodin
CAS No. : 481-72-1
(Synonyms: Rhabarberone; 3-Hydroxymethylchrysazine)
| Size | Price | Stock |
|---|---|---|
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| 5g | $50 | In-stock |
| 25g | $155 | Get quote |
| 100g | $515 | Get quote |
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| Cat. No. : | HY-N0189 |
| M.Wt: | 270.24 |
| Formula: | C15H10O5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 20.83 mg/mL |
Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with mTORC2 and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis[1]. Aloe emodin also exhibits antiviral activity that against influenza A virus[2].
In Vitro:Aloe emodin (0-15 μM; 24-96 h) inhibits PC3 cell proliferation in a dose-dependent manner[1].
Aloe emodin (0-15 μM; 24 h) inhibits the activation of mTORC2 downstream substrates, Akt and PKCα. Aloe emodin could bind with mTORC2 in cells and inhibit its kinase activity[1].
In Vivo:Aloe emodin (10-50 mg/kg) suppresses tumor growth by inhibiting mTOR complex2 activity[1].
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